Obesity negatively impacts corneal nerves in patients with diabetes mellitus

Table 5 Associations between body mass index and corneal nerve parameters in patients with diabetes

	Univariate analysis			Multivariate analysis*
Parameter	β	95% CI	P value	β	95% CI	P value
CNFD (no. of fibers/mm²)	− 0.22	− 0.28 to − 0.14	< 0.0001	− 0.21	− 0.29 to − 0.13	< 0.0001
CNFL (total length of fibers mm/mm²)	− 0.10	− 0.14 to − 0.06	< 0.0001	− 0.12	− 0.17 to − 0.07	< 0.0001
CNBD (no. of branch points on main fibers/mm²)	− 0.14	− 0.25 to − 0.03	0.01	− 0.17	− 0.30 to − 0.04	0.01
CTBD (total no. of branch points/mm²)	− 0.09	− 0.24 to 0.07	0.27	− 0.14	− 0.31 to 0.04	0.12
CNFA (total nerve fiber area mm²/mm²)	− 0.002	− 0.0001 to 0.0001	0.87	− 0.010	− 0.0001 to 0.0001	0.89
CNFW (average nerve fiber width mm/mm²)	0.02	0.02 to 0.02	0.09	0.02	0.02 to 0.02	0.12
CFracDim	− 0.0005	− 0.0010 to 0.0002	0.15	− 0.0006	− 0.0010 to 0.0001	0.27

Univariate and multivariate analyses were used
^*Adjusted for HbA1c, duration of diabetes, cholesterol, and triglyceride levels
P values in bold indicate statistical significance
CNFD = corneal nerve fiber density; CNBD = corneal nerve branch density; CNFL = corneal nerve fiber length; CTBD = corneal nerve fiber total branch density; CNFA = corneal nerve fiber area; CNFW = corneal nerve fiber width; CFracDim = corneal nerve fiber fractal dimension

ISSN: 2326-0254