Table 3 Difference in corneal nerve parameters between different BMI categories in patients with diabetes
From: Obesity negatively impacts corneal nerves in patients with diabetes mellitus
Parameter | Underweight (n = 9) | Normal (n = 221) | Overweight (n = 425) | Class I obesity (n = 121) | Class II obesity (n = 24) | Class III obesity (n = 7) | ANOVA P value |
|---|---|---|---|---|---|---|---|
CNFD (no. of fibers/mm2) | 16.6 ± 3.4 | 12.6 ± 4.9 | 12.1 ± 5.5 | 10.8 ± 5.1 | 10.1 ± 4.9 | 10.8 ± 4.8 |  < 0.0001 |
CNFL (total length of fibers mm/mm2) | 11.4 ± 1.6 | 8.7 ± 3.2 | 8.5 ± 3.1 | 8.1 ± 2.7 | 7.9 ± 2.5 | 7.7 ± 2.8 |  < 0.0001 |
CNBD (no. of branch points on main fibers/mm2) | 14.9 ± 3.8 | 11.0 ± 7.7 | 12.0 ± 0.4 | 10.4 ± 7.8 | 8.9 ± 6.4 | 11.4 ± 12.3 |  < 0.0001 |
CTBD (total no. of branch points/mm2) | 28.6 ± 14.2 | 18.3 ± 11.1 | 20.6 ± 13.1 | 18.6 ± 11.5 | 17.1 ± 9.9 | 20.4 ± 17.1 | 0.003 |
CNFA (total nerve fiber area mm2/mm2) | 0.0053 ± 0.0013 | 0.0039 ± 0.0018 | 0.0040 ± 0.0014 | 0.0041 ± 0.0013 | 0.0039 ± 0.0013 | 0.0033 ± 0.0015 | 0.04 |
CNFW (average nerve fiber width mm/mm2) | 0.0226 ± 0.0090 | 0.0219 ± 0.0011 | 0.0221 ± 0.0013 | 0.0221 ± 0.0011 | 0.0221 ± 0.0012 | 0.0223 ± 0.0013 | 0.11 |
CFracDim | 1.43 ± 0.02 | 1.39 ± 0.04 | 1.40 ± 0.05 | 1.39 ± 0.05 | 1.39 ± 0.04 | 1.36 ± 0.06 | 0.02 |
Corneal sensitivity (cm) | 28.5 ± 1.3 | 28.5 ± 2.3 | 28.8 ± 2.8 | 28.4 ± 2.9 | 28.2 ± 1.9 | 27.5 ± 2.0 | 0.24 |