Table 2 Tumour stage, histological risk factors, key genetics and time to metastasis and survival
Case No. | pT classification, stage and histology typea | Chr 1 | Chr 3 | Chr 6 | Chr 8 | Chr 9 | TCGA subgroupb | BAP 1 nuclear staining | Time to metastasis (months) | Survival post metastasis (months) | Total follow-up (months) | Cause of death |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
UM1 | pT1a, I, Spindle | – | – | – | – | – | A/Bc | Present | NA | NA | 154 | Non-UM related |
UM2* | pT4a, IIIA, Epithelioid | ND | Mono-somy 3 | ND | Gain 8 | ND | C | Loss | 48 (kidney) | 12 | 60 | UM related |
UM3 | pT4a, IIIA, Spindle | ND | ND | Gain 6p | ND | Loss 9p | A | Present | NA | NA | 6 | Non-UM related |
UM4 | pT2a, IIA, Epithelioid | ND | ND | ND | ND | ND | A | Present | NA | NA | 12 | Non-UM related |
UM5 | pT1a, I, Mixed | – | – | – | – | – | A/Bc | Present | NA | NA | 6 | Non-UM related |
UM6 | pT4b, IIIb, Mixed | ND | ND | Gain 6p Loss 6q | Gain 8q | Gain 9q | B | Present | NA | NA | 192 | Alive |
UM7* | pT3a, IIB, Spindle | ND | ND | Gain 6p Loss 6p | ND | ND | A | Present | 156 (lung) | 9 | 165 | UM related |
UM8 | pT2a, IIA, Spindle | – | – | – | – | – | A/Bc | Present | NA | NA | 156 | Alive |
UM9 | pT2a, IIA, Spindle | Gain 1p Loss 1p | ND | Gain 6p Loss 6p | ND | Gain 9q Loss 9p,9q | A | Present | NA | NA | 160 | Alive |
UM10* | pT4b, IIIB, Spindle | Gain 1q | ND | Gain 6p Loss 6p | Loss 8p | ND | A | Present | 34 (liver) | 17 | 51 | UM related |
UM11 | pT3a, IIB, Mixed | ND | ND | ND | ND | Gain 9q | A | Present | NA | NA | 144 | Alive |
UM12 | pT4b, IIIB, Mixed | – | – | – | – | – | A/Bc | Present | NA | NA | 15 | Non-UM related |
UM13 | pT4e, IIIC, Epithelioid | Loss 1p | CN-LOH 3p | Gain 6p Loss 6q | Gain 8q | ND | C | Hetero-genous loss | NA | NA | 91 | Non-UM related |
UM14 | pT4a, IIIA, Epithelioid | ND | ND | ND | ND | ND | A | Present | NA | NA | 96 | Alive |
UM15 | PT3a, IIB, Epithelioid, necrotic | ND | ND | ND | ND | ND | A | Present | NA | NA | 94 | Non-UM related |
UM16* | pT4a, IIIA, Spindle | – | – | – | – | – | C/Dc | Loss | 1 (liver) | 13 | 14 | UM related |
UM17 | PT3b, IIIA, Mixed | Gain 1q | ND | Gain 6p Loss 6q | Gain 8q, 8p | ND | B | Present | NA | NA | 60 | Alive |
UM18 | pT3a, IIB, Spindle | ND | ND | Gain 6p Loss 6p | Gain 8q | ND | B | Present | NA | NA | 84 | Alive |
UM19 | pT2b, IIB, Mixed | – | – | – | – | – | A/Bc | Present | NA | NA | 83 | Alive |
UM20 | pT2a, IIB Mixed | ND | Mono-somy 3 | ND | Gain 8q Loss 8p | ND | C | Loss | NA | NA | 72 | Alive |