Fig. 2

Comparison of the copy number profile between the SEA UM and TCGA-UM cohorts. a Copy number alteration (CNA) landscape of the local UM cohort (right panel, n = 14) compared with the TCGA-UM cohort (left panel, n = 80). Frequencies of chromosomal gains and losses on chromosomes 1, 3, 6, 8, and 9. b Kaplan–Meier survival curves comparing BAP1 expression levels. In the SEA UM cohort (left panel), survival is analysed based on BAP1 protein levels determined by immunohistochemistry (IHC), with red representing intact nuclear staining and blue representing loss of nuclear staining. In the TCGA-UM cohort (right panel), survival is analysed based on BAP1 gene expression levels, with “high” (red) and “low” (blue) expression categories. In both cohorts, low BAP1 expression (blue lines) is significantly associated with poorer survival compared to high expression (red lines). Statistical differences were calculated using the two-sided log-rank (Mantel-Cox) test, with time presented in years on the x-axis. c Association between CNAs and progression-free survival (PFS) in the SEA cohort (top panel) and the TCGA-UM cohort (bottom panel). Actual P values for each comparison are provided. Error bars represent the standard error of the mean (SEM). Significance levels: **P < 0.001; *P < 0.05; ns: not significant. TCGA, The Cancer Genome Atlas; SEA, Southeast Asian; UM, uveal melanoma