Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incision lenticule extraction (SMILE)

Table 5 Comparison of microneuroma parameters in CLEAR vs. SMILE

Parameter	CLEAR	SMILE	P value^a	P value^b	P value^c
Preoperative
Total area (µm²)	223.78 ± 135.29	202.46 ± 115.24	0.525	–	–
Perimeter (µm)	22.20 ± 7.02	21.44 ± 5.97	0.859	–	–
Postoperative month 1
Total area (µm²)	290.73 ± 163.79	337.50 ± 237.15	0.315	0.035	0.011
Perimeter (µm)	30.54 ± 6.28	28.22 ± 8.64	0.695	0.048	0.018
Postoperative month 3
Total area (µm²)	256.97 ± 133.82	239. 00 ± 170.59	0.248	0.584	0.537
Perimeter (µm)	26.34 ± 7.54	25.36 ± 6.36	0.569	0.323	0.052
Postoperative month 6
Total area (µm²)	246.27 ± 142.03	221.84 ± 110.21	0.891	0.436	0.318
Perimeter (µm)	26.13 ± 7.32	25.27 ± 7.21	0.384	0.370	0.252
Postoperative month 12
Total area (µm²)	246.70 ± 186.32	222.79 ± 153.66	0.708	0.965	0.190
Perimeter (µm)	25.63 ± 7.33	25.03 ± 5.77	0.333	0.895	0.361

P values in bold indicate statistical significance
CLEAR = corneal lenticule extraction for advanced refractive correction; SMILE = small incision lenticule extraction
^aCLEAR vs. SMILE eyes
^bPostoperative vs. preoperative for CLEAR eyes
^cPostoperative vs. preoperative for SMILE eyes

ISSN: 2326-0254