Skip to main content

Table 3 Comparison of corneal nerve parameters in CLEAR vs. SMILE

From: Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incision lenticule extraction (SMILE)

Parameter

CLEAR

SMILE

P valuea

P valueb

P valuec

Preoperative

     

 CNFD (/mm2)

16.11 ± 3.46

18.26 ± 4.06

0.169

–

–

 CNBD (/mm2)

14.05 ± 4.81

15.46 ± 3.86

0.387

–

–

 CNFL (mm/mm2)

9.14 ± 2.44

10.59 ± 2.60

0.121

–

–

 CTBD (/mm2)

20.34 ± 7.68

24.14 ± 9.17

0.228

–

–

 CNFA (mm2/mm2)

0.0044 ± 0.0010

0.0047 ± 0.0011

0.409

–

–

 CNFW (mm/mm2)

0.0225 ± 0.0019

0.0215 ± 0.0012

0.069

–

–

 CFracDim

1.41 ± 0.04

1.43 ± 0.03

0.102

–

–

Postoperative month 1

     

 CNFD (/mm2)

8.30 ± 4.15

8.90 ± 3.53

0.649

0.013

 < 0.001

 CNBD (/mm2)

5.28 ± 4.89

4.62 ± 3.14

0.643

0.009

 < 0.001

 CNFL (mm/mm2)

6.59 ± 2.18

6.50 ± 2.16

0.897

0.039

 < 0.001

 CTBD (/mm2)

11.16 ± 6.06

11.49 ± 5.14

0.865

0.009

0.003

 CNFA (mm2/mm2)

0.0012 ± 0.0028

0.0009 ± 0.0025

0.795

0.009

0.001

 CNFW (mm/mm2)

0.0208 ± 0.0025

0.0207 ± 0.0024

0.876

0.206

0.365

 CFracDim

1.36 ± 0.04

1.35 ± 0.05

0.410

0.027

 < 0.001

Postoperative month 3

     

 CNFD (/mm2)

7.08 ± 3.67

8.49 ± 3.45

0.249

 < 0.001

 < 0.001

 CNBD (/mm2)

3.83 ± 2.89

5.26 ± 3.84

0.226

 < 0.001

 < 0.001

 CNFL (mm/mm2)

6.01 ± 1.85

6.51 ± 2.04

0.457

 < 0.001

0.001

 CTBD (/mm2)

10.54 ± 4.24

11.66 ± 7.26

0.585

0.001

0.003

 CNFA (mm2/mm2)

0.0029 ± 0.0010

0.0030 ± 0.0012

0.743

0.001

0.003

 CNFW (mm/mm2)

0.0220 ± 0.0012

0.0216 ± 0.0011

0.292

0.479

0.969

 CFracDim

1.3437 ± 0.0445

1.3536 ± 0.0540

0.556

 < 0.001

 < 0.001

Postoperative month 6

     

 CNFD (/mm2)

7.08 ± 3.67

7.68 ± 3.82

0.605

 < 0.001

 < 0.001

 CNBD (/mm2)

3.83 ± 2.89

6.03 ± 4.38

0.593

 < 0.001

 < 0.001

 CNFL (mm/mm2)

6.01 ± 1.85

6.44 ± 2.15

0.829

0.002

0.001

 CTBD (/mm2)

11.10 ± 4.74

11.53 ± 4.67

0.804

 < 0.001

0.001

 CNFA (mm2/mm2)

0.0029 ± 0.0010

0.0033 ± 0.0010

0.406

 < 0.001

0.027

 CNFW (mm/mm2)

0.0220 ± 0.0012

0.0219 ± 0.0011

0.831

0.151

0.286

 CFracDim

1.34 ± 0.04

1.35 ± 0.04

0.952

0.005

 < 0.001

Postoperative month 12

     

 CNFD (/mm2)

10.11 ± 2.88

10.71 ± 3.06

0.646

0.010

 < 0.001

 CNBD (/mm2)

7.11 ± 4.95

6.70 ± 5.35

0.858

0.036

0.001

 CNFL (mm/mm2)

7.05 ± 1.57

6.90 ± 1.78

0.837

0.011

0.008

 CTBD (/mm2)

12.87 ± 4.17

12.86 ± 7.54

0.997

0.028

0.013

 CNFA (mm2/mm2)

0.0034 ± 0.0008

0.0031 ± 0.0011

0.433

0.053

0.052

 CNFW (mm/mm2)

0.0215 ± 0.0007

0.0210 ± 0.0007

0.097

0.852

0.637

 CFracDim

1.37 ± 0.03

1.36 ± 0.04

0.547

0.001

0.002

  1. P values in bold indicate statistical significance
  2. CLEAR = corneal lenticule extraction for advanced refractive correction; SMILE = small incision lenticule extraction; CNFD = corneal nerve fiber density; CNBD = corneal nerve branch density; CNFL = corneal nerve fiber length; CTBD = corneal total branch density; CNFA = corneal nerve fiber area; CNFW = corneal nerve fiber width; CFracDim = corneal nerve fiber fractal dimension
  3. aCLEAR vs. SMILE eyes
  4. bPostoperative vs. preoperative for CLEAR eyes
  5. cPostoperative vs. preoperative for SMILE eyes
Back to article page

Eye and Vision

ISSN: 2326-0254