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Table 2 Ocular surface assessment in CLEAR vs. SMILE

From: Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incision lenticule extraction (SMILE)

Parameter

CLEAR

SMILE

P valuea

P valueb

P valuec

Preoperative

     

 Corneal sensitivity (mm)

29.61 ± 1.25

28.19 ± 5.93

0.317

–

–

 Schirmer’s test value (mm)

16.94 ± 12.26

15.83 ± 11.31

0.779

–

–

 TBUT (s)

7.39 ± 2.66

7.42 ± 2.46

0.975

–

–

 Oxford Score

0.16 ± 0.37

0.11 ± 0.32

0.642

–

–

 NEI Score

0.32 ± 0.67

0.32 ± 0.58

1.000

–

–

Postoperative week 1

     

 Corneal sensitivity (mm)

26.25 ± 8.50

26.25 ± 7.78

1.000

0.124

0.168

 Schirmer’s test value (mm)

14.80 ± 11.91

14.13 ± 13.00

0.885

0.718

1.000

 TBUT (s)

5.61 ± 2.56

5.95 ± 2.50

0.679

0.003

0.009

 Oxford Score

0.26 ± 0.56

0.21 ± 0.42

0.745

0.429

0.429

 NEI Score

0.84 ± 1.50

0.37 ± 0.76

0.228

0.066

0.749

Postoperative month 1

     

 Corneal sensitivity (mm)

28.94 ± 2.016

28.69 ± 2.36

0.749

0.383

0.611

 Schirmer’s test value (mm)

12.33 ± 8.90

14.22 ± 11.32

0.582

0.067

0.501

 TBUT (s)

5.78 ± 2.21

5.26 ± 2.42

0.505

0.034

 < 0.001

 Oxford Score

0.16 ± 0.50

0.05 ± 0.23

0.411

1.000

0.578

 NEI Score

0.76 ± 1.70

0.29 ± 0.51

0.253

0.182

0.881

Postoperative month 3

     

 Corneal sensitivity (mm)

27.53 ± 4.09

27.53 ± 4.09

1.000

0.054

0.722

 Schirmer’s test value (mm)

15.42 ± 12.69

16.47 ± 11.52

0.801

0.284

0.918

 TBUT (s)

7.68 ± 2.37

6.69 ± 2.12

0.204

0.698

0.417

 Oxford Score

0.17 ± 0.51

0.11 ± 0.32

0.701

1.000

1.000

 NEI Score

0.44 ± 1.65

0.17 ± 0.51

0.501

0.734

0.269

Postoperative month 6

     

 Corneal sensitivity (mm)

29.06 ± 2.11

28.18 ± 3.11

0.340

0.392

0.959

 Schirmer’s test value (mm)

11.50 ± 8.64

11.38 ± 10.16

0.795

0.145

0.164

 TBUT (s)

7.11 ± 2.03

7.22 ± 1.99

0.869

0.685

0.712

 Oxford Score

0.11 ± 0.32

0.17 ± 0.51

0.701

0.668

0.717

 NEI Score

0.22 ± 0.55

0.17 ± 0.38

0.727

0.579

0.269

Postoperative month 12

     

 Corneal sensitivity (mm)

28.08 ± 4.35

28.08 ± 4.35

1.000

0.316

0.814

 Schirmer’s test value (mm)

9.42 ± 8.89

10.83 ± 11.78

0.743

0.093

0.294

 TBUT (s)

6.64 ± 1.60

7.00 ± 2.08

0.614

0.676

0.944

 Oxford Score

0.29 ± 0.61

0.14 ± 0.53

0.516

0.671

1.000

 NEI Score

0.21 ± 0.58

0.14 ± 0.53

0.737

0.385

0.272

  1. P values in bold indicate statistical significance
  2. CLEAR = corneal lenticule extraction for advanced refractive correction; SMILE = small incision lenticule extraction; TBUT = tear break-up time; NEI = National Eye Institute
  3. aCLEAR vs. SMILE eyes
  4. bPostoperative vs. preoperative for CLEAR eyes
  5. cPostoperative vs. preoperative for SMILE eyes
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Eye and Vision

ISSN: 2326-0254