Fig. 2

Single-variant association analyses for common variants. a Manhattan plot of the linear regression analysis for 814 keratoconus cases and 771 controls. The log10 (P value) from the final genome-wide association study (GWAS) summary is shown on the y-axis for all single-nucleotide polymorphisms (SNPs) along the different autosomes (x-axis). b Comparison of effect size of association for the same SNPs in the largest GWAS meta study and this study