Exploring optical coherence tomography parameters in eyes with myopic tilted disc

Zhang, Yu Qiao; Zhang, Xiu Juan; Shen, Ru Yue; Zhang, Yuzhou; Tang, Fang Yao; Szeto, Simon K. H.; Ng, Danny Siu-Chun; Kam, Ka Wai; Young, Alvin L.; Chen, Li Jia; Pang, Chi Pui; Tham, Clement C.; Yam, Jason C.; Chan, Poemen P.

doi:10.1186/s40662-024-00411-3

Eye and Vision

Table 3 Relationship between optic disc morphology and OCT parameters (adjusted by axial length)

From: Exploring optical coherence tomography parameters in eyes with myopic tilted disc

	Optic disc torsion angle (°)^a		OCT horizontal tilt angle (°)^b		Ovality index^c
Variables	Coefficient (95% CI)	P value	Coefficient (95% CI)	P value	Coefficient (95% CI)	P value
Macular GCIPL (μm)
Superonasal	− 0.30 × 10⁻² (− 0.02, 0.01)	0.72	− 0.05 (− 0.10, 0.08)	0.09	− 4.55 (− 8.29, − 0.82)	0.02
Inferonasal	− 0.01 (− 0.03, 0.01)	0.38	− 0.05 (− 0.11, 0.02)	0.20	− 2.61 (− 6.62, 1.40)	0.20
Inferior	− 0.90 × 10⁻² (− 0.03, 0.01)	0.30	− 0.02 (− 0.07, 0.04)	0.58	− 3.63 (− 7.18, − 0.08)	0.05
Inferotemporal	− 0.40 × 10^–2 (− 0.02, 0.02)	0.70	− 0.03 (− 0.10, 0.04)	0.48	− 3.49 (− 8.25, 1.26)	0.15
Superotemporal	− 0.30 × 10⁻² (− 0.02, 0.02)	0.76	− 0.07 (− 0.13, − 0.01)	0.02	− 1.77 (− 5.82, 2.28)	0.39
Superior	− 0.10 × 10⁻² (− 0.02, 0.02)	0.94	− 0.05 (− 0.09, 0.01)	0.05	− 3.34 (− 6.78, 0.10)	0.06
Peripapillary RNFL (μm)
p1	− 0.11 (− 0.20, − 0.01)	0.03	− 0.40 (− 0.68, 0.13)	< 0.01	− 48.31 (− 67.53, − 29.09)	< 0.01
p2	− 0.06 (− 0.13, 0.01)	0.11	− 0.33 (− 0.54, − 0.11)	< 0.01	− 34.91 (− 49.28, − 20.55)	< 0.01
p3	− 0.01 (− 0.06, 0.04)	0.69	− 0.14 (− 0.30, 0.02)	0.08	− 24.10 (− 36.54, − 11.67)	< 0.01
p4	− 0.70 × 10⁻² (− 0.07, 0.05)	0.82	− 0.19 (− 0.36, − 0.02)	0.03	− 33.98 (− 44.86, − 23.10)	< 0.01
p5	0.03 (− 0.06, 0.13)	0.52	− 0.39 (− 0.69, − 0.09)	0.01	− 36.16 (− 54.48, − 17.84)	< 0.01
p6	0.07 (− 0.04, 0.17)	0.21	− 0.36 (− 0.68, − 0.03)	0.03	− 14.23 (− 36.19, 7.74)	0.20
p7	0.04 (− 0.06, 0.14)	0.44	− 0.04 (− 0.41, 0.33)	0.85	24.58 (1.59, 47.55)	0.04
p8	− 0.01 (− 0.09, 0.07)	0.80	− 0.11 (− 0.39, 0.17)	0.44	37.74 (18.86, 56.62)	< 0.01
p9	0.06 (0.01, 0.12)	0.03	− 0.14 (− 0.32, 0.05)	0.15	32.03 (19.20, 44.86)	< 0.01
p10	0.14 (0.06, 0.23)	< 0.01	− 0.07 (− 0.36, 0.23)	0.64	49.86 (28.94, 70.78)	< 0.01
p11	− 0.03 (− 0.11, 0.06)	0.51	− 0.15 (− 0.44, 0.14)	0.32	4.41 (− 14.51, 23.34)	0.65
p12	− 0.12 (− 0.22, − 0.03)	0.01	− 0.43 (− 0.72, − 0.13)	< 0.01	− 19.00 (− 37.85, − 0.14)	0.05

OCT = optical coherence tomography; GCIPL = ganglion cell inner-plexiform layer; RNFL = retinal nerve fiber layer; CI = confidence interval
The p1–p12 represent the 12 segmentations of RNFL in clockwise and anti-clockwise directions for the right and left eye, respectively
In optic disc torsion angle, a positive value indicates optic disc torsion temporally, a negative value indicates optic disc torsion nasally. The generalized estimation equation was used, and it was adjusted for age, axial length, and other myopic tilted disc parameters (i.e., additionally adjusted for ^aOCT horizontal tilt angle and ovality index, ^boptic disc torsion angle and ovality index, and ^coptic disc torsion angle and OCT horizontal tilt angle)
P values in bold indicate statistical significance

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