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Table 4 IVCM features of CALT in various ocular diseases

From: A review of the application of in-vivo confocal microscopy on conjunctival diseases

Authors

Ocular disease

IVCM findings

Mastropasqua et al. [66]

Glaucoma

• Higher reflective reticular structures in follicles in glaucoma patients than in normal subjects

• More evident lymphocytic infiltration in follicles with topical combined therapy than with monotherapy

Mastropasqua et al. [56]

Dry eye

• Numerous lymphocytes infiltrate into the diffuse lymphoid layer, follicles, and follicular spaces

• Lymphocyte density increases and tend to cluster as dry eye advances

Liu et al. [125]

Meibomian gland dysfunction

• High density of diffuse lymphocytes, follicles, and perifollicular lymphocytes

• Great reflectivity of the central follicles

• Positive correlation between diffuse lymphocyte density and telangiectasia, and between central follicle reflection intensity and blockage

Liu et al. [126]

Infectious keratitis

• High density of diffuse lymphocytes, follicles, and perifollicular lymphocytes

• Large follicular area

• Great reflectivity of the central follicles

• Reduction of diffuse lymphocyte density, parafollicular lymphocyte density, and follicular area as keratitis improved

  1. IVCM = in-vivo confocal microscopy; CALT  = conjunctiva-associated lymphoid tissue