Table 1 Genotype distribution of IL-1RN 86 bp VNTR and IL-1β gene rs1143634, rs16944 polymorphisms in keratoconus cases and healthy controls

From: Inflammatory and genomic interactions within keratoconus susceptible patients: a nationwide registered case–control study

rs2234663 (86 bp VNTR)					rs16944 (T > C)					rs1143634 (C > T)
		Control	Case	P value	IL -1β		Control	Case	P value	IL -1β		Control	Case	P value
Female	LL	75	66	0.463	Female	CC	29	22	0.084	Female	CC	55	37	0.021
	LS	18	10			TC	54	42			TC	35	50
	SS	5	6			TT	16	27			TT	9	4
Male	LL	80	58	0.016	Male	CC	25	23	0.581	Male	CC	65	42	0.011
	LS	18	21			TC	54	55			TC	40	49
	SS	7	18			TT	27	19			TT	1	6
< 35 years	LL	100	83	0.216	< 35 years	CC	35	29	0.718	< 35 years	CC	76	55	0.064
	LS	25	23			TC	71	70			TC	52	67
	SS	9	16			TT	28	31			TT	6	8
> 35 years	LL	55	41	0.159	> 35 years	CC	19	16	0.773	> 35 years	CC	44	24	0.034
	LS	11	8			TC	37	27			TC	23	32
	SS	3	8			TT	15	15			TT	4	2
Total	LL	155	124	0.042	Total	CC	54	45	0.679	Total	CC	120	79	0.004
	LS	36	31			TC	108	97			TC	75	99
	SS	12	24			TT	43	46			TT	10	10
HWE	P = 0.000				HWE		P = 0.416			HWE		P = 0.693

HWE = Hardy–Weinberg equilibrium
P values in bold indicate statistical significance

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ISSN: 2326-0254

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