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Table 3 Optimal cut-off values of ChT, LA, and SA to classify pathological myopia using ROC curve analysis

From: Choroidal vascular changes in early-stage myopic maculopathy from deep learning choroidal analysis: a hospital-based SS-OCT study

Age (years)

Cut-off value

Sensitivity (%)

Specificity (%)

Youden index

AUC

SE

95% CI

P value

Optimal cut-off values of ChT, LA and SA at the vertical meridian

 All

  ChT_V (μm)

145.5

84.2

80.4

0.646

0.899

0.010

0.879 to 0.918

 < 0.001

  LA_V (mm2)

0.528

85.0

80.2

0.652

0.890

0.010

0.871 to 0.910

 < 0.001

  SA_V (mm2)

0.325

80.6

83.6

0.642

0.901

0.010

0.882 to 0.920

 < 0.001

 18 ≤ Age ≤ 30

  ChT_V (μm)

145.5

86.5

83.4

0.699

0.899

0.019

0.863 to 0.936

 < 0.001

  LA_V (mm2)

0.555

92.3

79.9

0.722

0.887

0.019

0.849 to 0.925

 < 0.001

  SA_V (mm2)

0.345

88.5

80.6

0.691

0.908

0.019

0.870 to 0.945

 < 0.001

 30 < Age ≤ 40

  ChT_V (μm)

147.5

77.3

80.1

0.574

0.863

0.019

0.825 to 0.902

 < 0.001

  LA_V (mm2)

0.528

76.1

81.5

0.576

0.860

0.020

0.822 to 0.899

 < 0.001

  SA_V (mm2)

0.354

80.7

74.6

0.553

0.860

0.020

0.822 to 0.899

 < 0.001

 40 < Age ≤ 50

  ChT_V (μm)

135.6

89.3

83.7

0.730

0.922

0.016

0.890 to 0.953

 < 0.001

  LA_V (mm2)

0.522

93.3

75.2

0.685

0.907

0.018

0.872 to 0.942

 < 0.001

  SA_V (mm2)

0.325

92.0

83.7

0.757

0.930

0.014

0.902 to 0.958

 < 0.001

 50 < Age ≤ 60

  ChT_V (μm)

129.3

84.4

92.7

0.771

0.930

0.028

0.875 to 0.985

 < 0.001

  LA_V (mm2)

0.483

84.4

90.9

0.753

0.927

0.029

0.870 to 0.984

 < 0.001

  SA_V (mm2)

0.322

87.5

81.8

0.693

0.923

0.029

0.867 to 0.980

 < 0.001

Optimal cut-off values of ChT, LA and SA in the N2 region

 All

  ChT_N2 (μm)

82.4

89.5

78.5

0.680

0.916

0.008

0.900 to 0.933

 < 0.001

  LA_N2 (mm2)

0.076

89.1

78.6

0.677

0.908

0.009

0.890 to 0.926

 < 0.001

  SA_N2 (mm2)

0.049

89.1

75.5

0.646

0.895

0.009

0.877 to 0.914

 < 0.001

 18 ≤ Age ≤ 30

  ChT_N2 (μm)

84.9

96.2

78.2

0.744

0.924

0.015

0.894 to 0.954

 < 0.001

  LA_N2 (mm2)

0.076

92.3

80.6

0.729

0.917

0.017

0.884 to 0.950

 < 0.001

  SA_N2 (mm2)

0.043

88.5

83.0

0.715

0.913

0.015

0.883 to 0.943

 < 0.001

 30 < Age ≤ 40

  ChT_N2 (μm)

82.8

89.8

79.5

0.693

0.916

0.014

0.889 to 0.943

 < 0.001

  LA_N2 (mm2)

0.077

87.5

79.5

0.670

0.904

0.015

0.874 to 0.935

 < 0.001

  SA_N2 (mm2)

0.048

88.6

76.4

0.650

0.895

0.016

0.865 to 0.926

 < 0.001

 40 < Age ≤ 50

  ChT_N2 (μm)

75.1

85.3

86.3

0.716

0.920

0.016

0.889 to 0.951

 < 0.001

  LA_N2 (mm2)

0.073

90.7

78.8

0.695

0.907

0.017

0.873 to 0.941

 < 0.001

  SA_N2 (mm2)

0.043

85.3

84.4

0.697

0.909

0.017

0.876 to 0.943

 < 0.001

 50 < Age ≤ 60

  ChT_N2 (μm)

66.6

68.8

94.5

0.633

0.888

0.037

0.815 to 0.960

 < 0.001

  LA_N2 (mm2)

0.062

75.0

92.7

0.677

0.876

0.040

0.797 to 0.954

 < 0.001

  SA_N2 (mm2)

0.047

81.3

81.8

0.631

0.853

0.042

0.771 to 0.934

 < 0.001

  1. ChT = choroidal thickness; LA = luminal area; SA=Stromal area; ROC = receiver operating characteristic; AUC = area under the curve; SE = standard error; CI = confidence interval; ChT_V = the mean choroidal thickness at the vertical meridian; LA_V = the mean luminal area at the vertical meridian; SA_V = the mean stromal area at the vertical meridian; ChT_N2 = the mean choroidal thickness in the nasal perifoveal region; LA_N2 = the mean luminal area in the nasal perifoveal region; SA_N2 = the mean stromal area in the nasal perifoveal region. P values were determined by ROC curve analysis
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Eye and Vision

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