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Table 4 Linear mixed-effect model determination of factors associated with retinal layer thickness changes, showing significant reduction over time in the CRVO group

From: Longitudinal changes in each retinal layer thickness in patients with non-ischemic central retinal vein occlusion

Parameter

GCC

INL

OPL

ONL

 

B (95% CI)

P value

B (95% CI)

P value

B (95% CI)

P value

B (95% CI)

P value

Age

− 0.63 (− 1.02, − 0.23)

0.003

− 0.07 (− 0.23, 0.08)

0.359

− 0.11 (− 0.25, 0.03)

0.111

0.10 (− 0.13, 0.34)

0.387

Sex

9.65 (− 3.57, 22.88)

0.148

− 0.58 (− 5.27, 4.11)

0.804

3.12 (− 0.99, 7.23)

0.133

3.30 (− 3.77, 10.36)

0.353

DM

10.13 (− 6.99, 27.56)

0.239

2.62 (− 3.62, 8.86)

0.403

0.44 (− 5.21, 6.09)

0.876

0.51 (− 9.09, 10.11)

0.915

HTN

− 0.62 (− 14.62, 13.38)

0.929

2.95 (− 1.94, 7.85)

0.231

1.15 (− 3.30, 5.59)

0.606

2.94 (− 4.54, 10.43)

0.433

In.No

− 0.30 (− 3.35, 2.75)

0.843

0.73 (− 0.09, 1.57)

0.082

− 0.02 (− 0.77, 0.73)

0.952

− 0.62 (− 1.88, 0.64)

0.327

Duration

− 0.08 (− 0.53, 0.36)

0.703

0.055 (− 0.11, 0.21)

0.502

0.01 (− 0.14, 0.15)

0.931

0.03 (− 0.21, 0.27)

0.800

SE

0.84 (− 3.18, 4.87)

0.675

− 1.04 (− 2.38, 0.29)

0.123

− 0.73 (− 1.94, 0.48)

0.232

− 0.57 (− 2.66, 1.51)

0.583

IOP

− 0.24 (− 1.92, 1.43)

0.773

0.48 (− 0.09, 1.05)

0.094

0.12 (− 0.41, 0.64)

0.659

− 0.48 (− 1.36, 0.40)

0.275

AXL

7.84 (− 24.11, 39.80)

0.492

− 0.56 (− 4.95, 3.85)

0.748

0.45 (− 5.70, 6.61)

0.857

− 6.88 (− 18.66, 4.90)

0.193

BCVA

− 7.78 (− 13.62, − 1.97)

0.009

2.07 (− 0.03, 4.16)

0.054

− 1.81 (− 3.59, − 0.02)

0.047

− 7.68 (− 11.13, − 4.23)

< 0.001

  1. Values in boldface (P < 0.050) are statistically significant
  2. CRVO = central retinal vein occlusion; GCC = ganglion cell complex; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer; DM = diabetes mellitus; HTN = hypertension; In.No. = number of previous injections; Duration = duration from CRVO onset to baseline; SE = spherical equivalent; IOP = intraocular pressure; AXL = axial length; BCVA = best-corrected visual acuity