Fig. 8
From: Efficacy of RCI001 as a therapeutic candidate of dry eye disease in a modified mixed dry eye model
Mean fluorescein intensity (MFI) values of 4-HNE, NOX2, and NOX4 of conjunctiva (a–c) and those of NOX2 of cornea (d). The MFI values of RCI group in the CC were only significantly decreased compared to those of PBS group. PBS, phosphate buffered saline; PDE, 1% prednisolone acetate; Lifite, 5% Lifitegrast; RCI, RCI001; 4-HNE, 4-hydroxy-2-nonenal; NOX2, nicotinamide adenine dinucleotide phosphate oxidase 2; NOX4, nicotinamide adenine dinucleotide phosphate oxidase 4; DAPI, 4′,6-diamidino-2-phenylindole; n = 3 per group. Data are expressed as the mean ± standard error of the mean. *P < 0.05, one-way ANOVA with Tukey’s post hoc test