Fig. 3

Schematic diagram to demonstrate ZEB1 regulation of many genes involved in corneal injury repair. ZEB1 is mainly regulated by TGF-β to promote EMT and likely tissue scarring. ZEB1 also upregulates the inflammation master factor NFκB and the NV master factor VEGF, and downregulates the apoptotic factor TNF-α to promote corneal inflammation and to affect corneal injury repair. Casp8, caspase 8; Cdh1, E-cadherin or cadherin 1; Cdki, cyclin-dependent kinase inhibitor; EMT, epithelial-to-mesenchymal transition; Fn1, fibronectin 1; IL, interleukin; Itga5, integrin subunit alpha 5; Mmp, matrix metalloproteinase; NFκB, nuclear factor kappa B; NV, neovascularization; Plau, urokinase-type plasminogen activator; TGF-β, transforming growth factor beta; TNF-α, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor; Vim, vimentin; Zeb1, Zinc finger E-box binding homeobox 1