Fig. 5

Recurrent conjunctival papilloma treated with 5-fluorouracil (5-FU). a. A 78-year-old white female presented with a medially localized recurrence of a previously biopsy-proven poorly defined papilloma covering the entire right upper tarsal conjunctiva and treated with topical interferon 2 years earlier. Inlet: note the fine branching vascularization. b. After 4 cycles of 5-FU 1% (1 week on, 3 weeks off), the lesion significantly improved with decreased papillomatous appearance. 2 additional cycles of 5-FU led to tumor resolution. Unfortunately, the lesion recurred 11 months later